Zetia? is a cholesterol-lowering medication that works by selectively blocking cholesterol absorption in the small intestine. By reducing the amount of cholesterol entering the bloodstream, Zetia? lowers LDL cholesterol levels without affecting cholesterol synthesis in the liver. It is commonly used as add-on therapy with statins or as an alternative in patients who cannot tolerate statins, helping achieve improved lipid control and long-term cardiovascular protection.